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Index > Protein center > PDGFB(Gene name) > Human
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  • PDGFB (Gene name),
  • Platelet-derived growth factor subunit B (Protein name ),  PDGFB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    PDGFB(PDGF2;SIS);
    Protein name:
    Platelet-derived growth factor subunit B(PDGF subunit B);
    Alternative:
    Platelet-derived growth factor B chain;PDGF-2;Proto-oncogene c-Sis;Platelet-derived growth factor beta polypeptide;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with XLKD1.
    Function:
    Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    241
    Sequence:
    50:
    MNRCWALFLS | LCCYLRLVSA | EGDPIPEELY | EMLSDHSIRS | FDDLQRLLHG | 
    100:
    DPGEEDGAEL | DLNMTRSHSG | GELESLARGR | RSLGSLTIAE | PAMIAECKTR | 
    150:
    TEVFEISRRL | IDRTNANFLV | WPPCVEVQRC | SGCCNNRNVQ | CRPTQVQLRP | 
    200:
    VQVRKIEIVR | KKPIFKKATV | TLEDHLACKC | ETVAAARPVT | RSPGGSQEQR | 
    241:
    AKTPQTRVTI | RTVRVRRPPK | GKHRKFKHTH | DKTALKETLG | A
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    MIM:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human PDGF subunit B
    Cat.:
    E0633m
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    Packing:
    96T
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    ELISA Kit for Human PDGF subunit B
    MSDS:
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    ELISA Kit for Human PDGF subunit B
    Cat.:
    E0633r
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    Packing:
    96T
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    ELISA Kit for Human PDGF subunit B
    Cat.:
    E0633h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PDGF subunit B
    Cat.:
    E0633d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PDGF subunit B
    Cat.:
    U0633d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PDGF subunit B
    Cat.:
    U0633h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PDGF subunit B
    Cat.:
    U0633r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PDGF subunit B
    MSDS:
    Please sign in first.
    CLIA Kit for Human PDGF subunit B
    Cat.:
    U0633m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
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    Polyclonal Antibody for Human PDGF subunit B
    Cat.:
    P0633Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PDGF subunit B
    Cat.:
    P0633Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PDGF subunit B
    Polyclonal Antibody for Human PDGF subunit B
    Cat.:
    P0633Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PDGF subunit B
    Monoclonal Antibody for Human PDGF subunit B
    Monoclonal Antibody for Human PDGF subunit B
    Monoclonal Antibody for Human PDGF subunit B
    Monoclonal Antibody for Human PDGF subunit B
    Monoclonal Antibody for Human PDGF subunit B
    Protein for Human PDGF subunit B
    Protein for Human PDGF subunit B
    Protein for Human PDGF subunit B
    Protein for Human PDGF subunit B
    Protein for Human PDGF subunit B

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    Linearity
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    References
    1. 1.
      "Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor."
      Josephs S.F. , Ratner L. , Clarke M.F. , Westin E.H. , Reitz M.S. , Wong-Staal F.
      Science225:636-639(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis."
      Collins T. , Ginsburg D. , Boss J.M. , Orkin S.H. , Pober J.S.
      Nature316:748-750(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor."
      Ratner L. , Josephs S.F. , Jarrett R. , Reitz M.S. , Wong-Staal F.
      Nucleic Acids Res.13:5007-5018(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Oncogenic potential of the human platelet-derived growth factor transcriptional unit."
      Rao C.D. , Igarashi H. , Pech M.W. , Robbins K.C. , Aaronson S.A.
      Cold Spring Harb. Symp. Quant. Biol.51:959-966(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit."
      Rao C.D. , Igarashi H. , Chiu I.-M. , Robbins K.C. , Aaronson S.A.
      Proc. Natl. Acad. Sci. U.S.A.83:2392-2396(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Lung.
      tissue: Pancreas.
      tissue: Testis.
    11. 11.
      "A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein."
      Dirks R.P.H. , Onnekink C. , Jansen H.J. , de Jong A. , Bloemers H.P.J.
      Nucleic Acids Res.23:2815-2822(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-185 (ISOFORM 2)
      tissue: Choriocarcinoma.
    12. 12.
      "Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma."
      Simon M.-P. , Pedeutour F. , Sirvent N. , Grosgeorge J. , Minoletti F. , Coindre J.-M. , Terrier-Lacombe M.-J. , Mandahl N. , Craver R.D. , Blin N. , Sozzi G. , Turc-Carel C. , O'Brien K.P. , Kedra D. , Fransson I. , Guilbaud C. , Dumanski J.P.
      Nat. Genet.15:95-98(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-53;CHROMOSOMAL TRANSLOCATION WITH COL1A1
    13. 13.
      "Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor."
      Chiu I.-M. , Reddy E.P. , Givol D. , Robbins K.C. , Tronick S.R. , Aaronson S.A.
      Cell37:123-129(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-241
    14. 14.
      "The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain."
      Weich H.A. , Sebald W. , Schairer H.U. , Hoppe J.
      FEBS Lett.198:344-348(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-241 (ISOFORM 1)
    15. 15.
      "Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus."
      Waterfield M.D. , Scrace G.T. , Whittle N. , Stroobant P. , Johnsson A. , Wasteson A. , Westermark B. , Heldin C.H. , Huang J.S. , Deuel T.F.
      Nature304:35-39(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 82-112
    16. 16.
      "Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence."
      Antoniades H.N. , Hunkapiller M.W.
      Science220:963-965(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 82-110
    17. 17.
      "The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor."
      Johnsson A. , Heldin C.H. , Wasteson A. , Westermark B. , Deuel T.F. , Huang J.S. , Seeburg P.H. , Gray A. , Ullrich A. , Scrace G. , Stroobant P. , Waterfield M.D.
      EMBO J.3:921-928(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 153-200;PARTIAL PROTEIN SEQUENCE
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS;IMPORTANCE OF ARG-108 AND ILE-111 FOR RECEPTOR BINDING
    19. 19.
      "Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF."
      Andersson M. , Oestman A. , Baeckstroem G. , Hellman U. , George-Nascimento C. , Westermark B. , Heldin C.-H.
      J. Biol. Chem.267:11260-11266(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERCHAIN DISULFIDE BONDS
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;CHROMOSOMAL TRANSLOCATION WITH COL1A1
    22. 22.
      "Role of platelet-derived growth factors in physiology and medicine."
      Andrae J. , Gallini R. , Betsholtz C.
      Genes Dev.22:1276-1312(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN DEVELOPMENT AND DISEASE
    23. 23.
      "Crystal structure of human platelet-derived growth factor BB."
      Oefner C. , D'Arcy A. , Winkler F.K. , Eggimann B. , Hosang M.
      EMBO J.11:3921-3926(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS)
    24. 24.
      "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex."
      Shim A.H. , Liu H. , Focia P.J. , Chen X. , Lin P.C. , He X.
      Proc. Natl. Acad. Sci. U.S.A.107:11307-11312(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 21-185 IN COMPLEX WITH PDGFRB;SUBUNIT;DISULFIDE BONDS
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